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Montelukast is an inhibitor of the drug metabolizing enzyme CYP2C8, part of the cytochrome P450 system. Therefore, it is theoretically possible that the combination of montelukast with a CYP2C8 substrate (e.g. amodiaquine, an anti-malarial drug) could increase the plasma concentrations of the substrate.
The medical uses for Cysteinyl-leukotriene type 1 receptor antagonists are for chronic and prophylactic treatment of asthma. [3] [9] [10] Other indications have been approved by the FDA for montelukast and they are used for the prevention of exercise-induced bronchoconstriction (EIB), relief of symptoms of allergic rhinitis (AR) that is for relief of seasonal allergic rhinitis and perennial ...
There are two dosage forms for zafirlukast, notable for their age-adjustments. The 20 mg tablet is for adults and children older than age 12, whereas the 10 mg tablet is for children between the ages of 5 and 12. [1] Tablets should be stored at room temperature, out of direct sunlight, and away from sources of moisture. [1]
Singulair was a blockbuster product for Merck after its launch in 1998, offering relief Exclusive-US FDA finds widely used asthma drug impacts the brain Skip to main content
The earlier Young's rule [1] for calculating the correct dose of medicine for a child is similar: it states that the child dosage is equal to the adult dosage multiplied by the child's age in years, divided by the sum of 12 plus the child's age. Young's rule was named after Thomas Young (1773–1829), an English polymath, physician and ...
The recommended daily intake of vitamin D for healthy people varies by age, per the NIH. Children (1–18 years): 15 mcg or 600 IU ... When taken in the appropriate dosage as directed by a doctor ...
You’re looking to spend most of your time running in zone 2—or 60 to 70 percent of your heart rate max, which you can calculate by subtracting your age from 220, explains Coviello.
Pranlukast (brand name Onon, オノン) is a cysteinyl leukotriene receptor-1 antagonist.This drug works similarly to Merck & Co.'s montelukast (Singulair). It is widely used in Japan.