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DNA is a long polymer made from repeating units called nucleotides. [6] [7] The structure of DNA is dynamic along its length, being capable of coiling into tight loops and other shapes. [8] In all species it is composed of two helical chains, bound to each other by hydrogen bonds.
The double-helix model of DNA structure was first published in the journal Nature by James Watson and Francis Crick in 1953, [6] (X,Y,Z coordinates in 1954 [7]) based on the work of Rosalind Franklin and her student Raymond Gosling, who took the crucial X-ray diffraction image of DNA labeled as "Photo 51", [8] [9] and Maurice Wilkins, Alexander Stokes, and Herbert Wilson, [10] and base-pairing ...
In 1951, Pauling published the structure of the alpha helix, a fundamentally important structural component of proteins. In early 1953, Pauling published a triple helix model of DNA, which subsequently turned out to be incorrect. [3] Both Crick, and particularly Watson, thought that they were racing against Pauling to discover the structure of DNA.
1952: an X-ray diffraction image of DNA was taken by Raymond Gosling in May 1952, a student supervised by Rosalind Franklin. [30] 1953: DNA structure is resolved to be a double helix by James Watson, Francis Crick and Maurice Wilkins. [31] 1955: Alexander R. Todd determined the chemical makeup of nitrogenous bases.
Rosalind Franklin joined King's College London in January 1951 to work on the crystallography of DNA. By the end of that year, she established two important facts: one is that phosphate groups, which are the molecular backbone for the nucleotide chains, lie on the outside (it was a general consensus at the time that they were at the inside); and the other is that DNA exists in two forms, a ...
In the 1950s, three groups made it their goal to determine the structure of DNA. The first group to start was at King's College London and was led by Maurice Wilkins and was later joined by Rosalind Franklin. Another group consisting of Francis Crick and James Watson was at Cambridge. A third group was at Caltech and was led by Linus Pauling ...
Nucleic acid types differ in the structure of the sugar in their nucleotides–DNA contains 2'-deoxyribose while RNA contains ribose (where the only difference is the presence of a hydroxyl group). Also, the nucleobases found in the two nucleic acid types are different: adenine , cytosine , and guanine are found in both RNA and DNA, while ...
By November 1951, Wilkins had evidence that DNA in cells as well as purified DNA had a helical structure. [33] Alex Stokes had solved the basic mathematics of helical diffraction theory and thought that Wilkins's X-ray diffraction data indicated a helical structure in DNA. Wilkins met with Watson and Crick and told them about his results.