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Digitalis (i.e. extracts, including digoxin, from the plant genus Digitalis) was the first drug used to treat dropsy (swollen ankles—a symptom of heart failure) following its discovery by William Withering. [22] Alongside diuretics, it was the mainstay of treatment for heart
Digoxin helps alleviate symptoms and reduce hospitalizations related to heart failure, but it does not offer any mortality-reducing benefits. [86] Digoxin may be considered in patients who remain symptomatic despite receiving treatment with a first-line combination of an ACE inhibitor (or ARNI ), a beta-blocker , and a mineralocorticoid ...
Digitalis (/ ˌ d ɪ dʒ ɪ ˈ t eɪ l ɪ s / [2] or / ˌ d ɪ dʒ ɪ ˈ t æ l ɪ s / [3]) is a genus of about 20 species of herbaceous perennial plants, shrubs, and biennials, commonly called foxgloves. Digitalis is native to Europe, Western Asia, and northwestern Africa. The flowers are tubular in shape, produced on a tall spike, and vary in ...
The level of digoxin for treatment is typically 0.5-2 ng/mL. [8] Since this is a narrow therapeutic index, digoxin overdose can happen. A serum digoxin concentration of 0.5-0.9 ng/mL among those with heart failure is associated with reduced heart failure deaths and hospitalizations. [9]
Digitoxin is a cardiac glycoside used for the treatment of heart failure and certain kinds of heart arrhythmia. It is a phytosteroid and is similar in structure and effects to digoxin, though the effects are longer-lasting. Unlike digoxin, which is eliminated from the body via the kidneys, it is eliminated via the liver, and so can be used in ...
Digitalis lanata contains a powerful cardiac glycoside that may be used by patients with heart conditions. Digoxin (digitalin) is a drug that is extracted from D. lanata. [17] [18] It is used to treat some heart conditions such as atrial fibrillation and cardiac arrhythmias. [18]
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A case series of 147 patients showed that not all cases of acute digoxin overdose require anti‐digoxin Fab, nor should anti‐digoxin Fab dose be calculated based on ingested dose. In contrast, a higher mortality (7.6%) was noted in a case series of acute and chronic digoxin and digitoxin poisoning despite Fab being used first line.