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Antimicrobial resistance ... pharmacists can help tackle antibiotic resistance by: ... of AMR resistances in the food chain pipeline may have far-reaching ...
A CDC infographic on how antibiotic-resistant bacteria have the potential to spread from farm animals. The use of antibiotics in the husbandry of livestock includes treatment when ill (therapeutic), treatment of a group of animals when at least one is diagnosed with clinical infection (metaphylaxis [1]), and preventative treatment (prophylaxis).
In a literature review conducted by the Review of Antimicrobial Resistance 100 out of 139 studies found evidence of a link between antibiotic use in animals and antibiotic resistance in consumers. [6] When a gram-negative bacterial infection is suspected in a patient, one of the first-line options for treatment is in the fluoroquinolone family.
Resistance can then spread to other microbes and to other host organisms. Antimicrobial agents can also have direct toxic effects on people and animals, including damage to kidneys, endocrine glands, liver, teeth and bones. Antimicrobial therapy is justified when the benefits outweigh these risks.
Once a bacterium has been identified following microbiological culture, antibiotics are selected for susceptibility testing. [5] Susceptibility testing methods are based on exposing bacteria to antibiotics and observing the effect on the growth of the bacteria (phenotypic testing), or identifying specific genetic markers (genetic testing). [6]
Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition. [1] The term is used in the context of resistance that pathogens or cancers have "acquired", that is, resistance has evolved.
The Comprehensive Antibiotic Resistance Database (CARD) is a biological database that collects and organizes reference information on antimicrobial resistance genes, proteins and phenotypes. [ 1 ] [ 2 ] The database covers all types of drug classes and resistance mechanisms and structures its data based on an ontology.
Optimal antimicrobial activity is generally seen in quaternary ammonium compounds with a long chain length, containing 8-18 carbon atoms. [14] Increased activity is seen against gram-positive bacteria in polymers with a chain length of 12-14 carbon atoms, while improved activity against gram-negative bacteria is seen in polymers with a chain ...