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Microcephalin (MCPH1) is a gene that is expressed during fetal brain development. Certain mutations in MCPH1 , when homozygous , cause primary microcephaly —a severely diminished brain . [ 5 ] [ 6 ] [ 7 ] Hence, it has been assumed that variants have a role in brain development.
Abnormal spindle-like microcephaly-associated protein, also known as abnormal spindle protein homolog or Asp homolog, is a protein that in humans is encoded by the ASPM gene. [5] ASPM is located on chromosome 1, band q31 (1q31). [6] The ASPM gene contains 28 exons and codes for a 3477 amino-acid-long protein. [6]
Once this genomic evidence was acquired, Lahn and his team decided to find the specific gene or genes that allowed for or even controlled this rapid evolution. Two genes were found to control the size of the human brain as it develops. These genes are Microcephalin (MCPH1) and Abnormal Spindle-like Microcephaly (ASPM). The researchers at the ...
He gives examples of variation in two genes related to brain development: an allele of microcephalin that appeared about 37,000 years ago and is common in Europeans and East Asians, but rare in sub-Saharan Africans; and an allele of ASPM that appeared about 6,000 years ago and is common in Europeans, Middle Easterners and to a lesser extent ...
A new review reports that nine people taking semaglutide and tirzepatide — the active ingredient in GLP-1 medications — experienced vision issues, including three potentially blinding eye ...
Salk Institute researchers have identified a key protein that may help users of GLP-1 drugs such as Ozempic and Wegovy maintain muscle mass while losing weight.
A study [20] was conducted to help determine the evolution of the brain size within the sub family Homininae that tested the genes ASPM (abnormal spindle-like microcephaly associated) and MCHP1 (microcephalin-1) and their association with the human brain. In this study researchers discovered that the increase in brain size is correlated to the ...
Defense Secretary Pete Hegseth ordered an immediate pause on gender-affirming medical care procedures for all active-duty service members in a memo that was addressed to senior Pentagon leadership ...