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Anything that causes epilepsy causes epileptogenesis, because epileptogenesis is the process of developing epilepsy. Structural causes of epilepsy include neurodegenerative diseases , traumatic brain injury , stroke , brain tumor , infections of the central nervous system , and status epilepticus (a prolonged seizure or a series of seizures ...
Epilepsy in animals is a group of neurological disorders characterized by seizures, caused by uncontrolled, abnormal bursts of electrical activity in the brain. They can start and stop very abruptly and last any amount of time from a few seconds to a few minutes. [ 1 ]
Animal models of epilepsy have helped to advance the understanding of how normal brains develop epilepsy (a process known as Epileptogenesis), and have been used in pre-clinical trials of antiepileptic drugs. [1] Epilepsy is a set of syndromes which have in common a predisposition to recurrent epileptic seizures. [2]
In the definition, epilepsy is now called a disease, rather than a disorder. This was a decision of the executive committee of the ILAE, taken because the word disorder , while perhaps having less stigma than does disease , also does not express the degree of seriousness that epilepsy deserves.
There are many causes of seizures. Organ failure, medication and medication withdrawal, cancer, imbalance of electrolytes, hypertensive encephalopathy , may be some of its potential causes. [ 2 ] The factors that lead to a seizure are often complex and it may not be possible to determine what causes a particular seizure, what causes it to ...
Depending on the changes in stimuli intensity and duration, researchers add or take away levels according to the needs of the study. [15] While adaptations do exist to the Racine stages model, the original model has served as the backbone to the idea of creating a method for determining the intensity of a seizure.
Further research by Goddard on the characteristics of the kindling phenomenon led to his conclusion that kindling can be used to model human epileptogenesis, learning and memory. [9] The publication of these results opened a completely new niche for epilepsy research and has stimulated a significant number of studies on the subject of kindling ...
Animal experiments using rats have shown that epileptic seizures can be produced by injecting iron into the brain. [8] Iron catalyzes the formation of hydroxyl radicals by the Haber–Weiss reaction; [8] such free radicals damage brain cells by peroxidizing lipids in their membranes. [27]