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Cancer of unknown primary origin (CUP) is a cancer that is determined to be at the metastatic stage at the time of diagnosis, but a primary tumor cannot be identified. A diagnosis of CUP requires a clinical picture consistent with metastatic disease and one or more biopsy results inconsistent with a tumor cancer.
Most cancers continue to be called after their primary site, as in breast cancer or lung cancer for example, even after they have spread to other parts of the body. Cancer of unknown primary origin is cancer that is determined to be at the metastatic stage, but a primary tumor cannot be identified.
Prognosis and treatment is the same as for the most common type of ovarian cancer, which is epithelial ovarian cancer. [6] [7] The median survival of primary peritoneal carcinomas is usually shorter by 2–6 months time when compared with serous ovarian cancer. Studies show median survival varies between 11.3 and 17.8 months.
A phase II study of 56 patients with cancer of unknown primary origin, i.e. a very common (2% to 5% of all diagnosed cancers) and difficult to treat metastatic cancer in which the primary cancer is unknown) found that nivolumab had a small (overall complete plus partial response rate of ~20%) beneficial effect. [17]
Carcinoma of unknown primary site [ edit ] The term carcinoma has also come to encompass malignant tumors composed of transformed cells whose origin or developmental lineage is unknown (see cancer of unknown primary origin ; CUP), but that possess certain specific molecular, cellular, and histological characteristics typical of epithelial cells.
This classification is widely used by cancer registries. It is currently in its third revision (ICD-O-3). ... Pseudomyxoma peritonei with unknown primary site (C80.9)
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