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Cancer of unknown primary origin (CUP) is a cancer that is determined to be at the metastatic stage at the time of diagnosis, but a primary tumor cannot be identified. A diagnosis of CUP requires a clinical picture consistent with metastatic disease and one or more biopsy results inconsistent with a tumor cancer.
Most cancers continue to be called after their primary site, as in breast cancer or lung cancer for example, even after they have spread to other parts of the body. Cancer of unknown primary origin is cancer that is determined to be at the metastatic stage, but a primary tumor cannot be identified.
In these cases, doctors refer to the primary tumor as "unknown" or "occult," and the patient is said to have cancer of unknown primary origin (CUP) or unknown primary tumors (UPT). [32] It is estimated that 3% of all cancers are of unknown primary origin. [33]
Rarely there can be a metastatic neoplasm with no known site of the primary cancer and this is classed as a cancer of unknown primary origin.
Prognosis and treatment is the same as for the most common type of ovarian cancer, which is epithelial ovarian cancer. [6] [7] The median survival of primary peritoneal carcinomas is usually shorter by 2–6 months time when compared with serous ovarian cancer. Studies show median survival varies between 11.3 and 17.8 months.
Despite the generic-sounding name, "CUP" is a specific cancer diagnosis that requires extensive testing. Individuals should only be placed in this category if a reliable source reports that they died from a cancer in which doctors attempted to but could not identify a primary tumor , and not for people whose cancer type is unknown .
Cases of prostate cancer are on the rise in California, according to new research. A study by UC San Francisco (UCSF) included nearly 388,000 men who had prostate cancer between 2004 and 2021. The ...
Carcinoma of unknown primary site [ edit ] The term carcinoma has also come to encompass malignant tumors composed of transformed cells whose origin or developmental lineage is unknown (see cancer of unknown primary origin ; CUP), but that possess certain specific molecular, cellular, and histological characteristics typical of epithelial cells.
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