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The purpose of agglutination is to detect the presence of specific antigens or antibodies in samples of bodily fluids, such as blood, saliva, urine, or cerebrospinal fluid (CSF); as well as to identify specific strains of bacteria in microbiological cultures.
Blood Typing Agglutination: In blood typing, agglutination occurs when specific antibodies react with antigens present on the surface of red blood cells, determining a person’s blood group (e.g., A, B, AB, or O).
Agglutination is a reaction in which particles (as red blood cells or bacteria) suspended in a liquid collect into clumps usually as a response to a specific antibody. Agglutination (clumping) of red blood cells. This occurs in biology in two main examples:
In hematology, red cell agglutination or autoagglutination is a phenomenon in which red blood cells clump together, forming aggregates. It is caused by the surface of the red cells being coated with antibodies .
Agglutination is the visible expression of the aggregation of antigens and antibodies. Agglutination reactions apply to particulate test antigens that have been conjugated to a carrier. The carrier could be artificial (such as latex or charcoal particles) or biological (such as red blood cells).
Agglutination reactions are fundamental in the process of blood typing, providing a reliable method to determine an individual’s blood group. The procedure involves mixing a small sample of blood with specific antibodies that target known blood group antigens.
Agglutination of red blood cells is called hemagglutination. One common assay that uses hemagglutination is the direct Coombs’ test, also called the direct antihuman globulin test (DAT), which generally looks for nonagglutinating antibodies.