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Typical antipsychotics (also known as major tranquilizers, and first generation antipsychotics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia). Typical antipsychotics may also be used for the treatment of acute mania, agitation, and other conditions.
The atypical antipsychotics (AAP), also known as second generation antipsychotics (SGAs) and serotonin–dopamine antagonists (SDAs), [1] [2] are a group of antipsychotic drugs (antipsychotic drugs in general are also known as tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) largely introduced after the 1970s and used to treat psychiatric ...
The difference between first- and second-generation antipsychotics is a subject of debate. The second-generation antipsychotics are generally distinguishable by the presence of 5HT2A receptor antagonism and a corresponding lower propensity for extrapyramidal side effects compared to first-generation antipsychotics. [15]
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Toggle Antipsychotics subsection. 1.1 Antipsychotic esters. 1.1.1 Typical antipsychotics. 1.1.2 Atypical antipsychotics. 2 See also. 3 References. 4 External links.
Chlorpromazine was developed in 1950 and was the first antipsychotic on the market. [7] [8] It is on the World Health Organization's List of Essential Medicines. [9] [10] Its introduction has been labeled as one of the great advances in the history of psychiatry. [11] [12] It is available as a generic medication. [6]