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The pain medication paracetamol (acetaminophen) is the first line treatment for osteoarthritis. [61] [95] Pain relief does not differ according to dosage. [62] However, a 2015 review found acetaminophen to have only a small short-term benefit with some concerns on abnormal results for liver function test. [96]
Non-steroidal anti-inflammatory drugs [1] [3] (NSAID) [1] are members of a therapeutic drug class which reduces pain, [4] decreases inflammation, decreases fever, [1] and prevents blood clots. Side effects depend on the specific drug, its dose and duration of use, but largely include an increased risk of gastrointestinal ulcers and bleeds ...
Several approved drugs are being investigated as repurposed agents in the treatment of osteoarthritis such as liraglutide (anti-diabetic and anti-obesity drug: NCT02905864), Metformin (anti-diabetic drug: NCT04767841, NCT05034029), Zoledronic acid (anti-osteoporotic drug: NCT04303026), etc. [4] Paroxetine has been deemed to have DMOAD activity ...
As a result, the PRAC has introduced additional proposals to manage diacerein’s risks and was satisfied that with new restrictions diacerein’s benefit on pain outweighs the side effects for osteoarthritis treatment. [8] The following recommendations have been made around the use of diacerein:
heartburn lasting more than a week requires medical attention; aspirin and NSAIDs should be avoided [60] chronic back pain paracetamol, NSAIDs [60] opioids may be necessary if other drugs do not control pain and pain is persistent [60] osteoarthritis pain paracetamol, NSAIDs [60] medical attention is recommended if pain persists. [60] fibromyalgia
The WHO guidelines recommend prompt oral administration of drugs ("by the mouth") when pain occurs, starting, if the patient is not in severe pain, with non-opioid drugs such as paracetamol (acetaminophen) or aspirin, [1] with or without "adjuvants" such as non-steroidal anti-inflammatory drugs (NSAIDs) including COX-2 inhibitors.
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