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  2. Pharmacodynamics of spironolactone - Wikipedia

    en.wikipedia.org/wiki/Pharmacodynamics_of...

    Spironolactone has been identified as an inhibitor of NRG1‐ERBB4 signaling. [142] Spironolactone has been found to act as a potent inhibitor of the pannexin 1 channel, and this action appears to be involved in its antihypertensive effects independently of MR antagonism. [143] Spironolactone has been found to block hERG channels. [144]

  3. Spironolactone - Wikipedia

    en.wikipedia.org/wiki/Spironolactone

    The time to onset of spironolactone-induced gynecomastia has been found to be 27 ± 20 months at low doses and 9 ± 12 months at high doses. [133] Gynecomastia induced by spironolactone usually regresses after a few weeks following discontinuation of the medication. [ 110 ]

  4. Feminizing hormone therapy - Wikipedia

    en.wikipedia.org/wiki/Feminizing_hormone_therapy

    Spironolactone is an antimineralocorticoid (antagonist of the mineralocorticoid receptor) and potassium-sparing diuretic, ... 3–6 months: 2–3 years: Unknown

  5. Hair Loss in Women: Everything You Need to Know - AOL

    www.aol.com/hair-loss-women-everything-know...

    It may take three to six months to notice a difference. Spironolactone. Spironolactone is a once-a-day tablet that can stop hair loss from progressing and encourage new hair growth.

  6. Spirolactone - Wikipedia

    en.wikipedia.org/wiki/Spirolactone

    SC-5233 (6,7-dihydrocanrenone), the C17α propanoic acid lactone of testosterone (androst-4-en-17β-ol-3-one), is the unsubstituted parent or prototype compound of the spirolactones, and is one of a few of the simplest members of the series along with SC-8109 (the 19-demethyl analogue of SC-5233) and canrenone (the 1,2-didehydro analogue of SC ...

  7. 8 of the Best Hair Loss Treatments for Women - AOL

    www.aol.com/8-best-hair-loss-treatments...

    3. Spironolactone. Another androgen- and DHT-targeting treatment that can work for women is spironolactone. It’s sometimes prescribed off-label to treat hair loss that occurs due to polycystic ...

  8. RALES (trial) - Wikipedia

    en.wikipedia.org/wiki/RALES_(trial)

    Spironolactone has become a standard therapy for reducing mortality and morbidity in patients with severe heart failure with reduced ejection fraction. [ 2 ] [ 3 ] The RALES trial has then paved the way for further studies on the role of aldosterone antagonists in heart failure and other cardiovascular conditions.

  9. Curly, unruly, fast-growing. For women, chin hair is normal ...

    www.aol.com/lifestyle/curly-unruly-fast-growing...

    “Prescription creams like eflornithine can help slow hair growth, while hormonal treatments, such as birth control pills or anti-androgens like spironolactone, can address the root cause of ...