Search results
Results From The WOW.Com Content Network
Thioacetic acid is an organosulfur compound with the molecular formula CH 3 C(O)SH. It is a thioic acid: the sulfur analogue of acetic acid (CH 3 C(O)OH), as implied by the thio-prefix. It is a yellow liquid with a strong thiol-like odor. It is used in organic synthesis for the introduction of thiol groups (−SH) in molecules. [4]
One route to thioesters involves the reaction of an acid chloride with an alkali metal salt of a thiol: [1] RSNa + R'COCl → R'COSR + NaCl. Another common route entails the displacement of halides by the alkali metal salt of a thiocarboxylic acid. For example, thioacetate esters are commonly prepared by alkylation of potassium thioacetate: [1]
At neutral pH, thiocarboxylic acids are fully ionized. Thiocarboxylic acids are about 100 times more acidic than the analogous carboxylic acids. Thiobenzoic acid has a pK a of 2.48 compared with 4.20 for benzoic acid, and thioacetic acid has a pK a near 3.4 compared with 4.72 for acetic acid. [8]
The reaction was first reported in 1949 with thioacetic acid as reagent [3] [4] and rediscovered in 2009. [5] It is used in click chemistry [ 6 ] [ 7 ] [ 8 ] and in polymerization , especially with dendrimers .
In a common application, potassium thioacetate is combined with alkylating agents to give thioacetate esters (X = halide): . CH 3 COSK + RX → CH 3 COSR + KX. Hydrolysis of these esters affords thiols:
Deli Yürek: Bumerang Cehennemi ("Crazy Heart: Boomerang Hell") is a 2001 Turkish action film, written and directed by Osman Sınav. It is spun off from the TV series Deli Yürek . [ 1 ]
Tetradecylthioacetic acid (TTA) is a synthetic fatty acid used as a nutritional supplement. TTA acts as a peroxisome proliferator-activated receptor alpha (PPARα) agonist and increases mitochondrial fatty acid oxidation in vitro . [ 1 ]
S-Methyl thioacetate is a natural product found in many plant species. In its pure form it has an unpleasant sulfurous smell, but when highly diluted and along with other simple alkyl thioacetates and related compounds, it is an important component of the smell and flavour profile of some foods, especially Camembert cheese.