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The virus causes measles, a highly contagious disease transmitted by respiratory aerosols that triggers a temporary but severe immunosuppression.Symptoms include fever, cough, runny nose, inflamed eyes and a generalized, maculopapular, erythematous rash and a pathognomonic Koplik spot seen on buccal mucosa opposite to lower 1st and 2nd molars.
An electron micrograph of the measles virus. Measles is caused by the measles virus, a single-stranded, negative-sense, enveloped RNA virus of the genus Morbillivirus within the family Paramyxoviridae. [51] The virus is highly contagious and is spread by coughing and sneezing via close personal contact or direct contact with secretions. [52 ...
Subacute sclerosing panencephalitis (SSPE), also known as Dawson disease, is a rare form of progressive brain inflammation caused by a persistent infection with the measles virus. The condition primarily affects children, teens, and young adults.
Symptoms can begin seven to 14 days after exposure to the measles virus, according to the CDC. The disease can cause severe complications and death in rare cases. Symptoms can include:
Viral pathogenesis is the study of the process and mechanisms by which viruses cause diseases in their target hosts, often at the cellular or molecular level. It is a specialized field of study in virology. [1] Pathogenesis is a qualitative description of the process by which an initial infection causes disease. [2]
[7] [8] Measles virus uses a protein on its surface called hemagglutinin, or just H protein, to bind to a target receptor on the host cell, which could be CD46, which is expressed on all nucleated human cells, CD150, aka signaling lymphocyte activation molecule or SLAM, which is found on immune cells like B or T cells, and antigen-presenting ...
Most recent reported cases of measles in Portugal are originally imported from other European countries (United Kingdom, France and Romania), Africa (Angola, South African and Ethiopia) and Asia (China). [144] Since 2004, Portugal reported 22 confirmed cases of measles. Virus isolates from 2005 and 2008 outbreaks belong the genotype D4. [145]
In early months of 2019, a measles outbreak occurred in the Portland metropolitan area, including the Clark County, Washington suburbs, in the United States. At the time, the outbreak was the largest outbreak in more than two decades; [1] outbreaks in 2019 in areas including Brooklyn [2] and Rockland County, New York [3] have since seen far greater numbers of cases.