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[1] [2] The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (delta-9-THC), the primary psychoactive compound in cannabis. [ 3 ] [ 4 ] Cannabidiol (CBD) is also a major constituent of temperate cannabis plants and a minor constituent in tropical varieties. [ 5 ]
Cannabinoids (/ k ə ˈ n æ b ə n ɔɪ d z ˌ ˈ k æ n ə b ə n ɔɪ d z /) are compounds found in the cannabis plant or synthetic compounds that can interact with the endocannabinoid system. [1] [2] The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (Delta-9-THC), the primary intoxicating compound in cannabis.
Kief (from Arabic كيف kīf, "Joy, pleasure" [1] [2]), sometimes transliterated as keef, also known as "Dust" and "Chief" a.k.a cannabis crystals among other names, refers to the pure and clean collection of loose cannabis trichomes, which are accumulated by being sifted from cannabis flowers or buds with a mesh screen or sieve.
[9] [10] Inside the transcriptomes of glandular trichomes in the cannabis plant, the pathway for cannabinoid production takes place. [9] Beginning with the formation of 3,5,7-trioxododecaneoyl-COA by the condensation reaction between hexanoyl-CoA and malonyl-CoA , catalyzed by type III polyketide synthase (PKS), the product is then used to form ...
Gaoni and Mechoulam [25] also described a method for converting CBD to Δ9-THC comprising refluxing a mixture of CBD in ethanol containing 0.05% hydrogen chloride for 2 hours. Percentage yield of Δ9-THC (Δ1-THC) was 2%. [26] [27] Using boron trifluoride, the yield was 70% [28] although purity was not given. [29]
The Single Convention is the main international treaty related to Cannabis sativa L. and its products.In its Article 1, the Single Convention defines "cannabis" as the "flowering or fruiting tops of the cannabis plant (excluding the seeds and leaves when not accompanied by the tops) from which the resin has not been extracted, by whatever name they may be designated;" while "cannabis resin" is ...
[3] [22] Following oral administration, concentrations of THC and its major active metabolite 11-hydroxy-THC (11-OH-THC) peak after 0.5 to 4 hours, with median time to peak of 1.0 to 2.5 hours at different doses. [22] [3] In some cases, peak levels may not occur for as long as 6 hours. [3]