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Harrison's groove, also known as Harrison's sulcus, is a horizontal groove along the lower border of the thorax corresponding to the costal insertion of the diaphragm; it is usually caused by chronic asthma or obstructive respiratory disease.
The prominent knobs of bone at the costochondral joints of rickets patients are known as a rachitic rosary or beading of the ribs.The knobs create the appearance of large beads under the skin of the rib cage, hence the name by analogy with the beads of a Catholic Christian rosary.
[2] [3] The analogous condition in adults is osteomalacia. The most common cause of rickets is a vitamin D deficiency , although hereditary genetic forms also exist. [ 2 ] This can result from eating a diet without enough vitamin D , dark skin, too little sun exposure, exclusive breastfeeding without vitamin D supplementation, celiac disease ...
osteomalacia (adults), rickets (children), fractures, enthesopathy, spinal stenosis, abnormal gait, short stature, tinnitus, hearing loss, dental complications, in rare exceptions Chiari malformation can occur. Causes: A genetic mutation of the PHEX gene results in elevated FGF23 hormone. Medication: phosphate, vitamin-D or burosumab
Osteomalacia in children is known as rickets, and because of this, use of the term "osteomalacia" is often restricted to the milder, adult form of the disease. Signs and symptoms can include diffuse body pains, muscle weakness, and fragility of the bones.
Autosomal dominant hypophosphatemic rickets (ADHR) is a rare hereditary disease in which excessive loss of phosphate in the urine leads to poorly formed bones , bone pain, and tooth abscesses. ADHR is caused by a mutation in the fibroblast growth factor 23 (FGF23). ADHR affects men and women equally; symptoms may become apparent at any point ...
For treating rickets, the American Academy of Pediatrics (AAP) has recommended that pediatric patients receive an initial two to three months of treatment with "high-dose" vitamin D therapy. In this regime, the daily dose of cholecalciferol is 1000 IU for newborns, 1000 to 5000 IU for 1- to 12-month-old infants, and 5000 IU for patients over 1 ...
Rickettsialpox is a mite-borne infectious illness caused by bacteria of the genus Rickettsia (Rickettsia akari). [1] Physician Robert Huebner and self-trained entomologist Charles Pomerantz played major roles in identifying the cause of the disease after an outbreak in 1946 in a New York City apartment complex, documented in "The Alerting of Mr. Pomerantz," an article by medical writer Berton ...