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Volatile anaesthetic agents share the property of being liquid at room temperature, but evaporating easily for administration by inhalation. The volatile anesthetics used in the developed world today include: Desflurane, isoflurane and sevoflurane. Other agents widely used in the past include ether, chloroform, enflurane, halothane, methoxyflurane.
Dental anesthesia (or dental anaesthesia) is the application of anesthesia to dentistry. It includes local anesthetics , sedation , and general anesthesia. Local anesthetic agents in dentistry
Several inhalational anesthetic agents are used in dentistry, e.g., isoflurane, sevoflurane, desflurane, and halothane. [11] The most concerning from the point of view of its health impact, however, is nitrous oxide, an inhalation sedative commonly used in dentistry, particularly for children.
The Meyer-Overton correlation for anaesthetics. A nonspecific mechanism of general anaesthetic action was first proposed by Emil Harless and Ernst von Bibra in 1847. [9] They suggested that general anaesthetics may act by dissolving in the fatty fraction of brain cells and removing fatty constituents from them, thus changing activity of brain cells and inducing anaesthesia.
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A lower MAC value represents a more potent volatile anesthetic. Other uses of MAC include MAC-BAR (1.7–2.0 MAC), which is the concentration required to block autonomic reflexes to nociceptive stimuli, and MAC-awake (0.3–0.5 MAC), the concentration required to block voluntary reflexes and control perceptive awareness.
Halothane, sold under the brand name Fluothane among others, is a general anaesthetic. [5] It can be used to induce or maintain anaesthesia. [5] One of its benefits is that it does not increase the production of saliva, which can be particularly useful in those who are difficult to intubate. [5]
The GWP of a halogenated anesthetic is up to 2,000 times greater than CO₂. The use of these anesthetics in healthcare is a significant contributor to hospital-related greenhouse gas emissions. There is a growing focus on identifying lower-GWP alternatives or enhancing recovery and recycling technologies for anesthetic gases. [20]