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Damage to hair cells can cause damage to the vestibular system and therefore cause difficulties in balancing. However, other vertebrates, such as the frequently studied zebrafish, and birds have hair cells that can regenerate. [5] [6] The human cochlea contains on the order of 3,500 inner hair cells and 12,000 outer hair cells at birth. [7]
[5] [6] Furthermore, Hensen's cells are also able to regenerate the damaged hair cells in some vertebrates; they undergo phagocytosis to eject the dead or injured hair cells, and reproduce both new hair cells and supporting cells into the cell cycle. One of the reasons is that the supporting cells are differentiated by the embryonic hair cells ...
Hair is a stratified squamous keratinized epithelium made of multi-layered flat cells whose rope-like filaments provide structure and strength to the hair shaft. The protein called keratin makes up hair and stimulates hair growth. Hair follows a specific growth cycle with three distinct and concurrent phases: anagen, catagen, and telogen. Each ...
In the adolescent mouse, inner ear supporting cell-to-hair cell transdifferentiation can be induced by the overexpression of hair cell fate-determining transcription factor Atoh1. [30] In the adult inner ear, overexpression of Atoh1 in supporting cells alone is inefficient in promoting hair cell regeneration. [ 31 ]
A hair pulled out in this phase will have the bulb of keratin attached to it which appears as a small white ball on the end of the hair. This process cuts the hair off from its blood supply and from the cells that produce new hair. When a club hair is completely formed, about a 2-week process, the hair follicle enters the telogen phase.
In the semicircular canals, the hair cells are found in the crista ampullaris, and the stereocilia protrude into the ampullary cupula. Here, the stereocilia are all oriented in the same direction. In the otoliths, the hair cells are topped by small, calcium carbonate crystals called otoconia. Unlike the semicircular ducts, the kinocilia of hair ...
For example, each human cell has about 1.8 meters of DNA if completely stretched out; however, when wound about histones, this length is reduced to about 9 micrometers (0.09 mm) of 30 nm diameter chromatin fibers. [3] There are five families of histones, which are designated H1/H5 (linker histones), H2, H3, and H4 (core histones).
It has been found that the tip links are relatively stiff, so it is thought that there has to be something else in the hair cells that is stretchy which allows the stereocilia to move back and forth. [5] It is hypothesized that the tip link is attached to the myosin motor which moves along actin filaments. [6]