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The sodium–potassium pump (sodium–potassium adenosine triphosphatase, also known as Na + /K +-ATPase, Na + /K + pump, or sodium–potassium ATPase) is an enzyme (an electrogenic transmembrane ATPase) found in the membrane of all animal cells. It performs several functions in cell physiology. The Na + /K +-ATPase enzyme is active (i.e. it ...
Another example is the hydrogen potassium ATPase (H + /K + ATPase or gastric proton pump) that acidifies the contents of the stomach. ATPase is genetically conserved in animals; therefore, cardenolides which are toxic steroids produced by plants that act on ATPases, make general and effective animal toxins that act dose dependently. [7]
Sodium/potassium-transporting ATPase subunit alpha-1 is an enzyme that in humans is encoded by the ATP1A1 gene. [ 5 ] The protein encoded by this gene belongs to the family of P-type cation transport ATPases , and to the subfamily of Na + /K + -ATPases .
Sodium/potassium-transporting ATPase subunit beta-3 is an enzyme that in humans is encoded by the ATP1B3 gene. [5] [6] [7] ATP1B3 has also been designated as CD298 (cluster of differentiation 298). The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases.
The Na + /K +-ATPase, as well as effects of diffusion of the involved ions, are major mechanisms to maintain the resting potential across the membranes of animal cells.. The relatively static membrane potential of quiescent cells is called the resting membrane potential (or resting voltage), as opposed to the specific dynamic electrochemical phenomena called action potential and graded ...
98660 Ensembl ENSG00000018625 ENSMUSG00000007097 UniProt P50993 Q6PIE5 RefSeq (mRNA) NM_000702 NM_178405 RefSeq (protein) NP_000693 NP_848492 Location (UCSC) Chr 1: 160.12 – 160.14 Mb Chr 1: 172.1 – 172.13 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Sodium/potassium-transporting ATPase subunit alpha-2 is a protein which in humans is encoded by the ATP1A2 gene. Function The ...
Na + /K +-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle.
Sodium/potassium-transporting ATPase subunit beta-1 is an enzyme that in humans is encoded by the ATP1B1 gene. [ 5 ] The protein encoded by this gene belongs to the family of Na + /K + and H + /K + ATPases beta chain proteins, and to the subfamily of Na + /K + -ATPases.