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In general, proton pump inhibitors are well tolerated, and the incidence of short-term adverse effects is relatively low. The range and occurrence of adverse effects are similar for all of the PPIs, though they have been reported more frequently with omeprazole. This may be due to its longer availability and, hence, clinical experience.
[5] [6] More serious side effects may include severe allergic reactions, a type of chronic inflammation known as atrophic gastritis, Clostridioides difficile colitis, low magnesium, and vitamin B12 deficiency. [5] Use in pregnancy appears to be safe. [5] Pantoprazole is a proton pump inhibitor that decreases gastric acid secretion. [5]
When these medications are used long term, the lowest effective dose should be taken. [4] They may also be taken only when symptoms occur in those with frequent problems. [5] Proton-pump inhibitors are named using the suffix "-prazole". There is a purported correlation (but no proven causal link) between the use of PPIs and the risk of dementia ...
Common side effects include nausea, vomiting, headaches, abdominal pain, and increased intestinal gas. [1] [14] Serious side effects may include Clostridioides difficile colitis, an increased risk of pneumonia, an increased risk of bone fractures, and the potential of masking stomach cancer. [1] Whether it is safe for use in pregnancy is ...
It is a proton pump inhibitor (PPI), used to treat peptic ulcer disease, gastroesophageal reflux disease, and Zollinger–Ellison syndrome. [5] Its effectiveness is similar to that of other PPIs. [6] It is taken by mouth. [4] Onset is over a few hours and effects last up to a couple of days. [4]
Effectiveness is similar to other proton pump inhibitors (PPIs). [8] It is taken by mouth. [6] Common side effects include constipation, feeling weak, and throat inflammation. [6] Serious side effects may include osteoporosis, low blood magnesium, Clostridioides difficile infection, and pneumonia. [6] Use in pregnancy and breastfeeding is of ...
The mechanism of action of proton pump inhibitors in a gastric parietal cell. PPI irreversibly inhibits H+/K+ ATPase proton pump on gastric parietal cells to create a profound, long-lasting antisecretory effect on gastric acid. [61] [64]
Long-term use of proton pump inhibitors in patients treated for Helicobacter pylori has been shown to dramatically increase the risk of gastric cancer. [33] Acute tubulointerstitial nephritis is a possible adverse reaction when using proton pump inhibitors. [9]