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High fructose consumption can lead to excess pyruvate production, causing a buildup of Krebs cycle intermediates. [60] Accumulated citrate can be transported from the mitochondria into the cytosol of hepatocytes, converted to acetyl CoA by citrate lyase and directed toward fatty acid synthesis.
GLUT5 is a fructose transporter expressed on the apical border of enterocytes in the small intestine. [5] GLUT5 allows for fructose to be transported from the intestinal lumen into the enterocyte by facilitated diffusion due to fructose's high concentration in the intestinal lumen.
Unlike glucose, fructose is not an insulin secretagogue, and can in fact lower circulating insulin. [4] In addition to the liver, fructose is metabolized in the intestines, testis, kidney, skeletal muscle, fat tissue and brain, [5] [6] but it is not transported into cells via insulin-sensitive pathways (insulin regulated transporters GLUT1 and ...
Humans can consume a variety of carbohydrates, digestion breaks down complex carbohydrates into simple monomers (monosaccharides): glucose, fructose, mannose and galactose. After resorption in the gut , the monosaccharides are transported, through the portal vein , to the liver, where all non-glucose monosacharids (fructose, galactose) are ...
The phosphotransferase system is involved in transporting many sugars into bacteria, including glucose, mannose, fructose and cellobiose. PTS sugars can differ between bacterial groups, mirroring the most suitable carbon sources available in the environment every group evolved.
Fructose can be bad for your health when consumed as part of high-fructose corn syrup in processed foods. Past studies have linked high-fructose corn syrup intake to many diseases, including cancer.
Most foods can be brought through a security checkpoint, the TSA said in a news release, but there are some items that can only be transported in a checked bag. To make holiday planning easier on ...
In pancreatic beta cells, free flowing glucose is required so that the intracellular environment of these cells can accurately gauge the serum glucose levels. All three monosaccharides (glucose, galactose, and fructose) are transported from the intestinal mucosal cell into the portal circulation by GLUT2. Is a high-frequency and low-affinity ...