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Agranulocytosis, also known as agranulosis or granulopenia, is an acute condition involving a severe and dangerous lowered white blood cell count (leukopenia, most commonly of neutrophils) and thus causing neutropenia in the circulating blood. [1] It is a severe lack of one major class of infection-fighting white blood cells.
Hypergonadotropic hypogonadism (HH), also known as primary or peripheral/gonadal hypogonadism or primary gonadal failure, is a condition which is characterized by hypogonadism which is due to an impaired response of the gonads to the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and in turn a lack of sex steroid production. [1]
Men and women exhibit different symptoms for hypergonadism. A few of the symptoms that men can experience are increased sex drive, early balding, excessive muscle mass, and acne. Women can have symptoms such as, increased growth of facial hair, deepened voice, coarse body hair, and an irregular menstrual cycle. [5]
Lack of testicle development in men (size < 4 ml, whereas the normal range is between 12 and 25 ml). [2] Primary amenorrhoea (failure to start menstruation). [8] Poorly defined secondary sexual characteristics. [3] Micropenis in 5-10% of male cases. [2] Cryptorchidism (undescended testicles) at birth. [2] Low levels of the gonadotropins LH and ...
In men, it causes impaired muscle and body hair development, gynecomastia, decreased height, erectile dysfunction, and sexual difficulties. If hypogonadism is caused by a disorder of the central nervous system (e.g., a brain tumor ), then this is known as central hypogonadism .
Abnormal breast enlargement in men [12] Augmented calcium levels in the blood (by as much as 25% – known as hypercalcaemia). This can cause stomach upset, excessive urination, and impaired kidney function. [13] Diabetes may be activated or intensified, and its control worsened. The diabetes is ameliorated or may disappear when the ...
Absolute neutrophil count (ANC) chronically less than 500/mm 3, usually less than 200/mm 3, is the main sign of SCN. Other elements include the severity of neutropenia, the chronology (from birth; not emerging later), and other normal findings (hemoglobin, platelets, general body health). [26]
Acromegaly is a disorder that results in excess growth of certain parts of the human body. It is caused by excess growth hormone (GH) after the growth plates have closed. The initial symptom is typically enlargement of the hands and feet. [3]