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Experts explain proven and new rescue therapies and migraine prevention protocols as well as which patients should and shouldn't try them.
For patients who require preventive therapy with symptoms such as more than 4 migraines per month or migraines lasting longer than 12 hours, first-line drugs for the prevention of migraine attacks include beta blockers, antidepressants, and anti convulsants.
Amitriptyline has been more frequently studied of the antidepressants and is the only antidepressant with fairly consistent support for efficacy in migraine prevention [citation needed]. The method of headache prevention with antidepressants is uncertain, but does not result from treating masked depression .
Rescue treatment involves acute symptomatic control with medication. [4] Recommendations for rescue therapy of migraine include: (1) migraine-specific agents such as triptans, CGRP antagonists, or ditans for patients with severe headaches or for headaches that respond poorly to analgesics, (2) non-oral (typically nasal or injection) route of administration for patients with vomiting, (3) avoid ...
Amitriptyline, sold under the brand name Elavil among others, is a tricyclic antidepressant primarily used to treat major depressive disorder, and a variety of pain syndromes such as neuropathic pain, fibromyalgia, migraine and tension headaches. [12]
More than 13% of U.S. adults use antidepressants—including 18% of women and 8% of men—according to data the Centers for Disease Control and Prevention collected from 2015–18. The COVID-19 ...
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