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Glomerular filtration rate (GFR) is the volume of fluid filtered from the renal (kidney) glomerular capillaries into the Bowman's capsule per unit time. [4] Central to the physiologic maintenance of GFR is the differential basal tone of the afferent (input) and efferent (output) arterioles (see diagram).
The Glomerular filtration rate (GFR) is regarded as the best overall measure of the kidney's ability to carry out these numerous functions. An estimate of the GFR is used clinically to determine the degree of kidney impairment and to track the progression of the disease. The GFR, however, does not reveal the source of the kidney disease.
The primary cause of the lack of clarity surrounding the GFR levels that indicate hyperfiltration is their strong reliance on age. [12] Glomerular hyperfiltration has traditionally been characterized as an elevated whole-kidney GFR, or a GFR greater than two standard deviations above the mean GFR of healthy individuals.
Along with the increase in pressure. At low perfusion pressures, Angiotensin II may act by constricting the efferent arterioles, thus mainlining the GFR and playing a role in autoregulation of renal blood flow. [3] People with poor blood flow to the kidneys caused by medications that inhibit angiotensin-converting enzyme may face kidney failure ...
In renal physiology, the filtration fraction is the ratio of the glomerular filtration rate (GFR) over the renal plasma flow (RPF). Filtration Fraction, FF = GFR/RPF, or =. The filtration fraction, therefore, represents the proportion of the fluid reaching the kidneys that passes into the renal tubules. It is normally about 20%.
Diabetic nephropathy is the most common cause of end-stage kidney disease, [13] [14] which may require hemodialysis or even kidney transplantation. [15] It is associated with an increased risk of death in general, particularly from cardiovascular disease .
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