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In patients with Alzheimer's disease (autosomal dominant hereditary), mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP) can be found. The majority of these cases carry mutant presenilin genes. An important part of the disease process in Alzheimer's disease is the accumulation of Amyloid beta (Aβ
Presenilin-1 (PS-1) is a presenilin protein that in humans is encoded by the PSEN1 gene. [5] Presenilin-1 is one of the four core proteins in the gamma secretase complex, which is considered to play an important role in generation of amyloid beta (Aβ) from amyloid-beta precursor protein (APP).
12266 Ensembl ENSG00000125730 ENSMUSG00000024164 UniProt P01024 P01027 RefSeq (mRNA) NM_000064 NM_009778 RefSeq (protein) NP_000055 NP_033908 Location (UCSC) Chr 19: 6.68 – 6.73 Mb Chr 17: 57.51 – 57.54 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Complement component 3, often simply called C3, is a protein of the immune system that is found primarily in the blood. It plays a ...
19165 Ensembl ENSG00000143801 ENSMUSG00000010609 UniProt P49810 Q61144 RefSeq (mRNA) NM_000447 NM_012486 NM_001128605 NM_011183 RefSeq (protein) NP_000438 NP_036618 NP_001122077 NP_035313 Location (UCSC) Chr 1: 226.87 – 226.93 Mb Chr 1: 180.05 – 180.09 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Presenilin-2 is a protein that (in humans) is encoded by the PSEN2 gene. Function ...
It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation.
WASHINGTON (Reuters) -The Justice Department late on Wednesday asked a U.S. appeals court to reject an emergency bid by TikTok to temporarily block a law that would require its Chinese parent ...
A protein precursor, also called a pro-protein or pro-peptide, is an inactive protein (or peptide) that can be turned into an active form by post-translational modification, such as breaking off a piece of the molecule or adding on another molecule. The name of the precursor for a protein is often prefixed by pro-.
The IMF on Thursday said its executive board completed the first review of an extended fund facility for Ecuador, allowing for an immediate disbursement of around $500 million. In a statement, the ...