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H 1 antagonists, also called H 1 blockers, are a class of medications that block the action of histamine at the H 1 receptor, helping to relieve allergic reactions.Agents where the main therapeutic effect is mediated by negative modulation of histamine receptors are termed antihistamines; other agents may have antihistaminergic action but are not true antihistamines.
The long-acting, over-the-counter medication lasts up to 24 hours per dose, according to the Food and Drug Administration (FDA). It reaches peak concentration in your body an hour after you take ...
It also has strong antihistaminergic effects. [11] [12] Mirtazapine came into medical use in the United States in 1996. [12] The patent expired in 2004, and generic versions are available. [12] [18] In 2022, it was the 105th most commonly prescribed medication in the United States, with more than 6 million prescriptions. [19] [20]
Diphenhydramine, sold under the brand name Benadryl among others, is an antihistamine and sedative. It is a first-generation H 1-antihistamine and it works by blocking certain effects of histamine, which produces its antihistamine and sedative effects. [11] [2] Diphenhydramine is also a potent anticholinergic. [12]
Fexofenadine is used for relief from physical symptoms associated with seasonal allergic rhinitis and for treatment of hives, including chronic urticaria. [12] It does not cure, but rather prevents the aggravation of allergic rhinitis and chronic idiopathic urticaria, and reduces the severity of the symptoms associated with those conditions, providing relief from repeated sneezing, runny nose ...
It acts primarily as a strong antagonist of the H 1 receptor (antihistamine, K i = 1.4 nM [29]) and a moderate mACh receptor antagonist (anticholinergic), [2] and also has weak to moderate affinity for the 5-HT 2A, [30] 5-HT 2C, [30] D 2, [31] [32] and α 1-adrenergic receptors, [33] where it acts as an antagonist at all sites, as well.