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In adult humans, Ets1 is expressed at high levels mainly in immune tissues such as thymus, spleen, and lymph node (B cells, T cells, NK cells, and NK T cells and non-lymphoid immune cells). An enforced expression of Ets1 blocks differentiation of B- and T-cells. By contrast, knocking Ets1 down causes multiple defects in the immune system.
There are 28 genes in humans, [4] 27 in the mouse, 10 in Caenorhabditis elegans and 9 in Drosophila. The founding member of this family was identified as a gene transduced by the leukemia virus, E26. The members of the family have been implicated in the development of different tissues as well as cancer progression.
(Link to human TFs annotation) IUPAC consensus (from selected PWM) AC008770.3: ENSG00000267179: C2H2 ZF: Likely sequence specific TF according to literature or domain structure – No motif : AC023509.3: ENSG00000267281: bZIP: Known motif – from protein with 100% identical DBD – in vitro : RTGACGTCAY AC092835.1: ENSG00000233757: C2H2 ZF
238037 Ensembl ENSG00000163026 ENSMUSG00000051721 UniProt Q9H6R7 Q6NV72 RefSeq (mRNA) NM_025203 NM_001142319 NM_001170858 NM_173416 RefSeq (protein) NP_001135791 NP_079479 NP_001164329 NP_775592 Location (UCSC) Chr 2: 24.03 – 24.05 Mb Chr 12: 4.89 – 4.91 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse WD Repeat and Coiled-coiled containing protein (WDCP) is a protein which in ...
In humans there are two distinct microRNAs that share an identical mature sequence, and these are called miR-1-1 and miR-1-2. ... ets1 is involved in extracellular ...
56501 Ensembl ENSG00000102034 ENSMUSG00000031103 UniProt Q99607 Q9Z2U4 RefSeq (mRNA) NM_001127197 NM_001421 NM_019680 NM_001381876 RefSeq (protein) NP_001120669 NP_001412 NP_062654 NP_001368805 Location (UCSC) Chr X: 130.06 – 130.11 Mb Chr X: 47.5 – 47.55 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse ETS-related transcription factor Elf-4 is a protein that in humans is encoded ...
If these CpG islands in ETS1 binding sites of the PARP1 promoter are epigenetically hypomethylated, PARP1 is expressed at an elevated level. [23] [24] Cells from older humans (69 to 75 years of age) have a constitutive expression level of both PARP1 and PARP2 genes reduced by half, compared to their levels in young adult humans (19 to 26 years ...
C11orf49 is a protein coding gene that in humans encodes for the C11orf49 protein. [5] It is heavily expressed in brain tissue and peripheral blood mononuclear cells, with the latter being an important component of the immune system.