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Interleukin 7 (IL-7) is a protein [5] that in humans is encoded by the IL7 gene. [6] [7] [8] IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by keratinocytes, [9] dendritic cells, [10] hepatocytes, [11] neurons, and epithelial cells, [12] but is not produced by normal ...
The nomenclature also proposes that IL-1F5 should be renamed to IL-36Ra, because it works as an antagonist to IL-36α, IL-36β and IL-36γ similar to how IL-1Ra works for IL-1α and IL-1β. Another revision was the renaming of IL-1F7 to IL-37 because this suppressing cytokine has many splicing variants , they should be called IL-37a, IL-37b and ...
Interleukin 10 (IL-10) is a protein that inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF, and GM-CSF produced by activated macrophages and by helper T cells. In structure, IL-10 is a protein of about 160 amino acids that contains four conserved cysteines involved in disulphide bonds. [ 33 ]
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Ig-like domain is the part of receptor which is located extracellularly. There are minimal homologies in amino acid sequences of Ig-like domains between proteins of IL-1R family but they all show characteristic Ig-fold and two β-sheets joined together by disulfide bonds which form between cysteine residues.
53603 Ensembl ENSG00000145777 ENSMUSG00000024379 UniProt Q969D9 Q9JIE6 RefSeq (mRNA) NM_033035 NM_138551 NM_021367 RefSeq (protein) NP_149024 NP_612561 NP_067342 Location (UCSC) Chr 5: 111.07 – 111.08 Mb Chr 18: 32.95 – 32.95 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-2 -like cytokine, alarmin, and growth factor ...
Cytokine receptor common subunit gamma also known as interleukin-2 receptor subunit gamma or IL-2RG is a protein that in humans is encoded by the IL2RG gene. [8] The human IL2RG gene is located on the long (q) arm of the X chromosome at position 13.1, from base pair 70,110,279 to base pair 70,114,423.
Interleukin-7 receptor subunit alpha (IL7R-α) also known as CD127 (Cluster of Differentiation 127) is a protein that in humans is encoded by the IL7R gene. [ 5 ] [ 6 ] IL7R-α is a type I cytokine receptor and is a subunit of the functional interleukin-7 receptor and thymic stromal lymphopoietin ( TSLP ) receptors.