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Another common finding is high blood calcium levels. [6] Multiple myeloma is considered treatable, but generally incurable. [3] Remissions may be brought about with steroids, chemotherapy, targeted therapy, and stem cell transplant. [3] Bisphosphonates and radiation therapy are sometimes used to reduce pain from bone lesions.
Elevated paraprotein level (above 30 g/L) in conjunction with end organ damage (elevated calcium, kidney failure, anemia, or bone lesions) or other biomarkers of malignancy, is diagnostic of multiple myeloma, according to the diagnostic criteria of the International Myeloma Working Group, [5] which were updated in 2014. [6]
Elevated levels of parathyroid hormone due to hyperparathyroidism, leading to bone resorption and subsequent hypercalcemia by reducing phosphate concentration. Secretion of parathyroid hormone-related protein by certain tumors. Resorption of bone due to Primary bone marrow tumors (e.g. multiple myeloma and leukemia)
Calcipotriene causes a rapid rise in calcium ion levels. [31] Calcium ion levels can remain high for weeks if untreated and lead to an array of medical issues. [31] There are also cases of hypercalcemia reported due to dogs ingesting rodenticides containing a chemical similar to calcipotriene found in psoriasis cream. [31]
There are a number of causes of hypercalciuria including genetic (idiopathic), primary hyperparathyroidism, immobilization, pagets disease, Multiple Myeloma, Calcium excess, Vitamin D excess/increased sensitivity, drug-induced hypercalciuria, sarcoidosis, hyperthyroidism, Cushing's disease, and renal tubular acidosis.
Multiple myeloma affects plasma cells, a type of white blood cell produced in the bone marrow. As a result, the cancer primarily affects the bones and kidneys. ... High calcium levels, anemia or ...