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CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells.CD1 glycoproteins are structurally related to the class I MHC molecules, however, in contrast to MHC class 1 proteins, they present lipids, glycolipids and small molecules antigens, from both endogenous and pathogenic proteins, to T cells and activate an immune ...
Complementarity-determining regions (CDRs) are polypeptide segments of the variable chains in immunoglobulins (antibodies) and T cell receptors, generated by B-cells and T-cells respectively. CDRs are where these molecules bind to their specific antigen and their structure/sequence determines the binding activity of the respective antibody.
PECAM-1 is a highly glycosylated protein with a mass of approximately 130 kDa. [9] The structure of this protein was determined by molecular cloning in 1990, when it was found out that PECAM-1 has an N-terminal domain with 574 amino acids, a transmembrane domain with 19 amino acids and a C-terminal cytoplasmic domain with 118 amino acids.
CD133 + melanoma cells are considered a subpopulation of CSC and play a critical role in recurrence. [21] Moreover, CD133 + melanoma cells are immunogenic and can be used as an antimelanoma vaccination. In mice the vaccination with CD133 + melanoma cells mediated strong anti-tumor activity that resulted in the eradication of parental melanoma ...
The immunoglobulin variable (IgV) domain of D 1 adopts an immunoglobulin-like β-sandwich fold with seven β-strands in two β-sheets, in a Greek key topology. [8] CD4 interacts with the β 2-domain of MHC class II molecules through its D 1 domain. T cells displaying CD4 molecules (and not CD8) on their surface, therefore, are specific for ...
CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). [1] It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains.
CD1d-presented lipid antigens activate a special class of T cells, known as natural killer T (NKT) cells, through the interaction with the T-cell receptor present on NKT membranes. [5] When activated, NKT cells rapidly produce Th1 and Th2 cytokines , typically represented by interferon-gamma and interleukin 4 production.
12511 Ensembl ENSG00000013725 ENSMUSG00000024670 UniProt P30203 Q61003 RefSeq (mRNA) NM_001254750 NM_001254751 NM_006725 NM_001037801 NM_009852 RefSeq (protein) NP_001241679 NP_001241680 NP_006716 NP_001032890 NP_033982 Location (UCSC) Chr 11: 60.97 – 61.02 Mb Chr 19: 10.77 – 10.81 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse CD6 (C luster of D ifferentiation 6) is a human ...