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The thymus (pl.: thymuses or thymi) is a specialized primary lymphoid organ of the immune system.Within the thymus, thymus cell lymphocytes or T cells mature. T cells are critical to the adaptive immune system, where the body adapts to specific foreign invaders.
The primary (or central) lymphoid organs, including the thymus, bone marrow, fetal liver and yolk sac, are responsible for generating lymphocytes from immature progenitor cells in the absence of antigens. [12] The thymus and the bone marrow constitute the primary lymphoid organs involved in the production and early clonal selection of ...
The thymus is a primary lymphoid organ of the immune system. It is a butterfly-shaped organ consisting of two lobes, located in the top part of the chest, that supports T cell development via specialized microenvironments that ensure a diverse, functional, and self-tolerant T cell population.
The mucosa-associated lymphoid tissue (MALT), also called mucosa-associated lymphatic tissue, is a diffuse system of small concentrations of lymphoid tissue found in various submucosal membrane sites of the body, such as the gastrointestinal tract, nasopharynx, thyroid, breast, lung, salivary glands, eye, and skin.
Hassall's corpuscles (also known as thymic bodies) are structures found in the medulla of the human thymus, formed from eosinophilic type VI thymic epithelial cells arranged concentrically. These concentric corpuscles are composed of a central mass, consisting of one or more granular cells, and of a capsule formed of epithelioid cells.
In mammals, B cells mature in the bone marrow and T cells mature in the thymus. [1] Central tolerance is not perfect, so peripheral tolerance exists as a secondary mechanism to ensure that T and B cells are not self-reactive once they leave primary lymphoid organs.
The thymus, as a primary lymphoid organ, mediates T cell development and maturation. The thymic microenvironment is established by TEC network filled with thymocytes (blood cell precursors of T cells) in different developing stages.
V(D)J recombination in mammals occurs in the primary lymphoid organs (bone marrow for B cells and thymus for T cells) and in a nearly random fashion rearranges variable (V), joining (J), and in some cases, diversity (D) gene segments.