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Letrozole, sold under the brand name Femara among others, is an aromatase inhibitor medication that is used in the treatment of breast cancer for post-menopausal women. [ 1 ] It was patented in 1986 and approved for medical use in 1996. [ 4 ]
Ovarian stimulation with the aromatase inhibitor letrozole has been proposed for ovulation induction in order to treat unexplained female infertility. In a multi-center study funded by the National Institute of Child Health and Development, ovarian stimulation with letrozole resulted in a significantly lower frequency of multiple gestation (i.e., twins or triplets) but also a lower frequency ...
[3] [4] [6] Food does not significantly influence the extent of absorption of anastrozole. [4] [6] Peak levels of anastrozole occur a median 3 hours after administration, but with a wide range of 2 to 12 hours. [2] [4] Steady-state levels of anastrozole are achieved within 7 to 10 days of continuous administration, with 3.5-fold accumulation.
Emotional lability is seen or reported in various conditions including borderline personality disorder, [3] histrionic personality disorder, [4] post-traumatic stress disorder, [5] hypomanic or manic episodes of bipolar disorder, [6] and neurological disorders or brain injury (where it is termed pseudobulbar affect), such as after a stroke. [7]
Appraisal: the emotional situation is evaluated and interpreted. Response: an emotional response is generated, giving rise to loosely coordinated changes in experiential, behavioral, and physiological response systems. Because an emotional response (4.) can cause changes to a situation (1.), this model involves a feedback loop from (4.)
The killing of a health care executive kicked off a firestorm of anger at a troubled system. The CEO of UnitedHealth responds to the concerns. UnitedHealth CEO: 'We understand people’s ...
4-Androstenedione for comparison. Exemestane is known chemically as 6-methylideneandrosta-1,4-diene-3,17-dione. Like the aromatase inhibitors formestane and atamestane, exemestane is a steroid that is structurally similar to 4-androstenedione, the natural substrate of aromatase. It is distinguished from the natural substance only by the ...
Reduced affect display, sometimes referred to as emotional blunting or emotional numbing, is a condition of reduced emotional reactivity in an individual. It manifests as a failure to express feelings either verbally or nonverbally, especially when talking about issues that would normally be expected to engage emotions.