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  2. Myasthenia gravis - Wikipedia

    en.wikipedia.org/wiki/Myasthenia_gravis

    Myasthenia gravis is an autoimmune disease of the neuromuscular junction which results from antibodies that block or destroy nicotinic acetylcholine receptors (AChR) at the junction between the nerve and muscle. [6][7][1] This prevents nerve impulses from triggering muscle contractions. [1]

  3. Acetylcholine receptor - Wikipedia

    en.wikipedia.org/wiki/Acetylcholine_receptor

    In myasthenia gravis, the receptor at the neuromuscular junction is targeted by antibodies, leading to muscle weakness. Muscarinic acetylcholine receptors can be blocked by the drugs atropine and scopolamine. Congenital myasthenic syndrome (CMS) is an inherited neuromuscular disorder caused by defects of several types at the neuromuscular ...

  4. Autoimmune autonomic ganglionopathy - Wikipedia

    en.wikipedia.org/wiki/Autoimmune_autonomic...

    Paraneoplastic syndrome, Guillain-Barré syndrome, diabetes, amyloidosis, Sjogren's syndrome, and Morvan syndrome. Autoimmune autonomic ganglionopathy is a type of immune-mediated autonomic failure that is associated with antibodies against the ganglionic nicotinic acetylcholine receptor present in sympathetic, parasympathetic, and enteric ganglia.

  5. Lambert–Eaton myasthenic syndrome - Wikipedia

    en.wikipedia.org/wiki/Lambert–Eaton_myasthenic...

    Myasthenia gravis is caused by autoantibodies to the postsynaptic acetylcholine receptors. Lambert–Eaton myasthenic syndrome (LEMS) is a rare autoimmune disorder characterized by muscle weakness of the limbs. It is also known as myasthenic syndrome, Eaton–Lambert syndrome, and when related to cancer, carcinomatous myopathy.

  6. Edrophonium - Wikipedia

    en.wikipedia.org/wiki/Edrophonium

    In practice, the edrophonium test has been replaced by testing for autoantibodies, including acetylcholine receptor (AchR) autoantibodies and muscle specific tyrosine kinase (MuSK) autoantibodies. [1] [2] Lambert-Eaton myasthenic syndrome (LEMS), is similar to myasthenia gravis in that it is an autoimmune disease.

  7. MuSK protein - Wikipedia

    en.wikipedia.org/wiki/MuSK_protein

    Antibodies directed against this protein (Anti-MuSK autoantibodies) are found in some people with myasthenia gravis not demonstrating antibodies to the acetylcholine receptor. [8] The disease still causes loss of acetylcholine receptor activity, [ 9 ] but the symptoms affected people experience may differ from those of people with other causes ...

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