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Aribit (Aripiprazole) tablets. Aripiprazole, sold under the brand names Abilify and Aristada, among others, is an atypical antipsychotic. [8] It is primarily used in the treatment of schizophrenia and bipolar disorder; [8] other uses include as an add-on treatment in major depressive disorder and obsessive–compulsive disorder (OCD), tic disorders, and irritability associated with autism. [8]
For example, aripiprazole will act as a dopamine agonist at lower concentrations, but blocks the receptor at higher concentrations. Unlike antagonist antipsychotics, which require only 65% to 70% D2 receptor occupancy to be effective, aripiprazole receptor binding at effective antipsychotic doses is 90% to 95%. Since aripiprazole has an ...
Aripiprazole, an atypical antipsychotic, ... Binding affinity K i [nM] toward cloned human receptors (unless otherwise specified) [Note 1] Drug name [125] [237] SERT
(Reuters) -The U.S. FDA approved Bristol Myers Squibb's schizophrenia drug on Thursday, providing patients with a treatment option that reduces symptoms of the mental disorder without common side ...
In Wikidata. Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions. SSRIs increase the extracellular level of the neurotransmitter serotonin by limiting its reabsorption (reuptake) into ...
Binding affinity of 5-HT 3 receptor antagonist [43] 5-HT 3 receptor antagonists Binding affinity (K d, K i, K 50) Species Tropisetron 11 nM Human Granisetron 1.44 nM Human Ondansetron 4.9 nM Human Palonosetron 31.6 nM Rat cerebral cortex, rabbit ileal myenteric plexus, guinea-pig ileal plexus Dolasetron 20.03 nM NG 108-15 Metoclopramide (non ...
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