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Specific target organ toxicity following repeated exposure, categories 1, 2; Aspiration hazard, categories 1, 2; e.g. chromium; GHS08: Serious Health hazard Acute toxicity (oral, dermal, inhalation), category 5; Eye irritation, category 2B; Reproductive toxicity – effects on or via lactation; no pictogram required
Specific target organ toxicity (STOT) [8] category distinguishes between single and repeated exposure for Target Organ Effects. All significant health effects, not otherwise specifically included in the GHS, that can impair function, both reversible and irreversible, immediate and/or delayed are included in the non-lethal target organ/systemic ...
Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. [1] Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a substructure of the organism, such as a cell (cytotoxicity) or an organ such as the liver (hepatotoxicity).
The Toxin and Toxin-Target Database (T3DB), [1] [2] also known as the Toxic Exposome Database, is a freely accessible online database of common substances that are toxic to humans, along with their protein, DNA or organ targets. The database currently houses nearly 3,700 toxic compounds or poisons described by nearly 42,000 synonyms.
End organ damage is severe impairment of ... in order to identify and source and target ... of worsening kidney function and magnesium toxicity. Systolic blood ...
Male rabbits, mice, rats and hamsters were used to test the effect of 4-IPO on. In all four species, the lung was a major target. In the hamsters and mice additional liver necrosis and renal necrosis, respectively, was detected. [2] 4-IPO can also threaten newborn calves. If they become exposed to 4-IPO it increases their susceptibility to ...
Reproductive toxicity: 2: Suspected of damaging fertility or the unborn child (H361) Specific target organ toxicity – repeated exposure: 2: May cause damage to organs through prolonged or repeated exposure (H373) Serious eye damage/eye irritation: 2: Causes serious eye irritation (H319) Acute toxicity – inhalation: 3: Toxic if inhaled (H331)
Compartments are usually defined by grouping organs or tissues with similar blood perfusion rate and lipid content (i.e. organs for which chemicals' concentration vs. time profiles will be similar). Ports of entry (lung, skin, intestinal tract...), ports of exit (kidney, liver...) and target organs for therapeutic effect or toxicity are often ...