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The cause of CIN is chronic infection of the cervix with HPV, especially infection with high-risk HPV types 16 or 18. It is thought that the high-risk HPV infections have the ability to inactivate tumor suppressor genes such as the p53 gene and the RB gene, thus allowing the infected cells to grow unchecked and accumulate successive mutations, eventually leading to cancer.
This kills cancer cells, but can also impact normal cells leading to adverse side effects. Common chemotherapy side effects include; hair loss, mouth sores, loss of appetite, diarrhea, nausea and vomiting, premature menopause, infertility, and damage to the blood-forming cells within bone marrow.
This is an accepted version of this page This is the latest accepted revision, reviewed on 16 February 2025. Cancer that originates in mammary glands Medical condition Breast cancer An illustration of breast cancer Specialty Surgical oncology Symptoms A lump in a breast, a change in breast shape, dimpling of the skin, fluid from the nipple, a newly inverted nipple, a red scaly patch of skin on ...
The cervix (pl.: cervices) or cervix uteri is a dynamic fibromuscular sexual organ of the female reproductive system that connects the vagina with the uterine cavity. [1] The human female cervix has been documented anatomically since at least the time of Hippocrates, over 2,000 years ago.
DNA microarrays have compared normal cells to breast cancer cells and found differences in the expression of hundreds of genes. Although the significance of many of those genetic differences is unknown, independent analyses by different research groups has found that certain groups of genes have a tendency to co-express.
Normal cells typically generate only about 30% of energy from glycolysis, [118] whereas most cancers rely on glycolysis for energy production (Warburg effect). [ 119 ] [ 120 ] But a minority of cancer types rely on oxidative phosphorylation as the primary energy source, including lymphoma , leukemia , and endometrial cancer . [ 121 ]
The goal of reconstructive surgery is the restoration of normal appearance and function. The choice of technique in reconstruction is dictated by the size and location of the defect. Excision and reconstruction of facial skin cancers are generally more challenging due to the presence of highly visible and functional anatomic structures in the face.
650 Normal delivery; 651 Multiple gestation. 651.0 Twins, unspec. 651.1 Triplets, unspec. 652 Malposition and malpresentation of fetus; 653 Disproportion; 654 Abnormality of organs and soft tissues of pelvis; 655 Known or suspected fetal abnormality affecting management of mother. 655.73 Fetal movements, decreased, antepartum