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The metanephrogenic blastema or metanephric blastema (or metanephric mesenchyme, or metanephric mesoderm) is one of the two embryological structures that give rise to the kidney, the other being the ureteric bud. The metanephric blastema mostly develops into nephrons, but can also form parts of the collecting duct system.
[17] [6] [18] Differences in kidney structure are the result of adaptations during evolution to variations in body mass and habitats (in particular, aridity) between species. [ 19 ] [ 20 ] [ 12 ] The cortex and medulla of the kidney contain nephrons , [ 21 ] each of which consists of a glomerulus and a complex tubular system. [ 22 ]
Metanephric adenoma (MA) is a rare, benign tumour of the kidney, that can have a microscopic appearance similar to a nephroblastoma (Wilms tumours), [1] or a papillary renal cell carcinoma. It should not be confused with the pathologically unrelated, yet similar sounding, mesonephric adenoma .
Each metanephric kidney is characterized by a large number of nephrons and a highly branched system of collecting tubules and ducts, [28] that open into the ureter. [48] Such branching in the metanephros is unique in relation to the pronephros and mesonephros. [ 44 ]
The ureteric bud, also known as the metanephric diverticulum, [1]: 50 is a protrusion from the mesonephric duct during the development of the urinary and reproductive organs. [ 2 ] [ 3 ] It later develops into a conduit for urine drainage from the kidneys, which, in contrast, originate from the metanephric blastema .
surgical removal Congenital mesoblastic nephroma , while rare, is the most common kidney neoplasm diagnosed in the first three months of life and accounts for 3-5% of all childhood renal neoplasms. [ 2 ] [ 3 ] It is generally non-aggressive and amenable to surgical removal, though there is a subtype that is more aggressive and tends to spread ...
Metanephric dysplastic hematoma of the sacral region (MDHSR) has been described by Cozzutto and Lazzaroni-Fossati in 1980, [1] by Posalaki et al. in 1981 [2] and by Cozzutto et al. in 1982. [3] Three additional cases were seen by Finegold.
During early development (approximately day 22 in humans), the pronephric duct forms from the intermediate mesoderm, ventral to the anterior somites. The cells of the pronephric duct migrate caudally whilst inducing adjacent mesenchyme to form the tubules of the initial kidney-like structure called the pronephros. [6]