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Cefepime/enmetazobactam, sold under the brand name Exblifep, is a medication used for the treatment of urinary tract infections. [ 1 ] [ 2 ] It is a fixed dose combination containing cefepime , a cephalosporin antibacterial; and enmetazobactam , a beta-lactamase inhibitor .
Cutaneous actinomycosis is a chronic disease that affects the deep subcutaneous tissue of the skin. Caused by an anaerobic, Gram-positive, filamentous type of bacteria in the genus Actinomyces, [1]: 270 invasion of the soft tissue leads to the formation of abnormal channels leading to the skin surface (external sinus tracts) that discharge pale yellow sulfur granules.
Cefepime has an extended spectrum of activity against Gram-positive and Gram-negative bacteria, with greater activity against both types of organism than third-generation agents. A 2007 meta-analysis suggested when data of trials were combined, mortality was increased in people treated with cefepime compared with other β-lactam antibiotics. [1]
Actinomycosis is a rare infectious bacterial disease caused by the gram-positive Actinomyces species. [1] The name refers to ray-like appearance of the organisms in the granules. About 70% of infections are due to either Actinomyces israelii or A. gerencseriae. [1] Infection can also be caused by Streptomyces somaliensis and Propionibacterium ...
Actinomyces bovis is a branching, Gram-positive, rod-shaped bacterium of the genus Actinomyces. [1] It is the causative agent of lumpy jaw in cattle, and occasionally causes actinomycosis infections in humans. [ 3 ]
Actinomyces is a genus of the Actinomycetia class of bacteria. They all are Gram-positive and facultatively anaerobic , growing best under anaerobic conditions. [ 2 ] Actinomyces species may form endospores , and while individual bacteria are rod-shaped , Actinomyces colonies form fungus -like branched networks of hyphae . [ 3 ]
Actinomyces and its associated species have, for a long time, been implicated in human infections, particularly those of the mouth, pharynx, distal esophagus, and genitourinary tract. [9] Within the last 10 years, A. massiliensis has been detected in blood, and most Actinomyces bacteremias stem from oral sources. [9]
The protocol includes twice-weekly blood tests and liver function tests; measurement of serum lactate levels, for early detection of lactic acidosis; a review of all medications taken by the patient, interrupting the use of those that may interact with linezolid; and periodic eye and neurological exams in patients set to receive linezolid for ...