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  2. Amitriptyline - Wikipedia

    en.wikipedia.org/wiki/Amitriptyline

    Amitriptyline, sold under the brand name Elavil among others, is a tricyclic antidepressant primarily used to treat major depressive disorder, and a variety of pain syndromes such as neuropathic pain, fibromyalgia, migraine and tension headaches. [12]

  3. Serotonin–norepinephrine–dopamine reuptake inhibitor

    en.wikipedia.org/wiki/Serotonin–norepinephrine...

    Although two-thirds of patients will ultimately respond to antidepressant treatment, one-third of patients respond to placebo, [20] and remission is frequently sub-maximal (residual symptoms). In addition to post-treatment relapse, depressive symptoms can even recur in the course of long-term therapy ( tachyphylaxis ).

  4. Fibromyalgia - Wikipedia

    en.wikipedia.org/wiki/Fibromyalgia

    Fibromyalgia as a stand-alone diagnosis is uncommon, as most fibromyalgia patients often have other chronic overlapping pain problems or mental disorders. [11] Fibromyalgia is associated with mental health issues like anxiety , [ 51 ] posttraumatic stress disorder , [ 4 ] [ 51 ] bipolar disorder , [ 51 ] alexithymia , [ 52 ] and depression.

  5. Switching Antidepressants: Safety, Side Effects & Other ... - AOL

    www.aol.com/switching-antidepressants-safety...

    Despite their side effects, some tricyclic antidepressants may be effective for improving depression symptoms when other, newer medications aren’t effective. Atypical antidepressants.

  6. Nortriptyline - Wikipedia

    en.wikipedia.org/wiki/Nortriptyline

    The symptoms and the treatment of an overdose are generally the same as for the other tricyclic antidepressants, including anticholinergic effects, serotonin syndrome and adverse cardiac effects. TCAs, particularly nortriptyline, have a relatively narrow therapeutic index , which increase the chance of an overdose (both accidental and intentional).

  7. Desipramine - Wikipedia

    en.wikipedia.org/wiki/Desipramine

    Desipramine, sold under the brand name Norpramin among others, is a tricyclic antidepressant (TCA) used in the treatment of depression. [8] It acts as a relatively selective norepinephrine reuptake inhibitor, though it does also have other activities such as weak serotonin reuptake inhibitory, α 1-blocking, antihistamine, and anticholinergic effects.

  8. Tricyclic antidepressant - Wikipedia

    en.wikipedia.org/wiki/Tricyclic_antidepressant

    The TCAs are used primarily in the clinical treatment of mood disorders such as major depressive disorder (MDD), dysthymia, and treatment-resistant variants. They are also used in the treatment of a number of other medical disorders, including cyclic vomiting syndrome (CVS) and anxiety disorders such as generalized anxiety disorder (GAD), social phobia (SP) also known as social anxiety ...

  9. Milnacipran - Wikipedia

    en.wikipedia.org/wiki/Milnacipran

    During its development for fibromyalgia, milnacipran was evaluated utilizing a composite responder approach.To be considered as a responder for the composite ‘treatment of fibromyalgia’ endpoint, each patient had to show concurrent and clinically meaningful improvements in pain, physical function, and global impression of disease status.