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Heteroscorpine (HS-1) is a component of the venom of the Thai giant scorpion Heterometrus laoticus. This species is a member of the scorpion family commonly known as giant forest scorpions, indigenous to large parts of South and South-East Asia.
Although the venom of a few spider and scorpion species can be very dangerous to humans, medical researchers are investigating the use of these venoms for the treatment of disorders ranging from cancer to erectile dysfunction. The medical industry also uses the blood of horseshoe crabs as a test for the presence of contaminant bacteria.
NTX accounts for only about 1% of the scorpion venom. [7] NTX is one of the best-studied toxic peptides from scorpion venoms . [ 6 ] It was the second purified toxin obtained from the genus Centruroides after neurotoxin II [ 8 ] and the first short peptide from scorpion venom to be reported in the literature. [ 9 ]
Charybdotoxin (ChTX) is a 37 amino acid neurotoxin from the venom of the scorpion Leiurus quinquestriatus hebraeus (deathstalker) that blocks calcium-activated potassium channels. [2] This blockade causes hyperexcitability of the nervous system. It is a close homologue of agitoxin and both toxins come from Leiurus quinquestriatus hebraeus.
The crude venom of T. serrulatus contains different toxins. Some of the strongest derivates are the neurotoxins tityustoxin and toxin Ts-g. [3] Two types of toxins are considered to be responsible for the main toxic effect: toxin gamma (a β-type toxin) and tityustoxin (TsTX, an α-type toxin), both with a specific affinity to the sodium channel. [4]
The venom from Leiurus abdullahbayrami can be very toxic. The venom of this species is one of the most potent venoms of the Turkish scorpions, and it provokes severe symptoms in the victims. Proteins make up half of the dry weight of the crude venom. The venom in this species stimulates voltage-gated sodium and potassium channels. [11]
SPOILER WARNING: Do not read if you haven’t seen “Venom: Let There Be Carnage,” currently playing in theaters. At the end of 2018’s “Venom,” audiences saw serial killer Cletus Kasady ...
Parabuthus transvaalicus is a dangerous, medically significant scorpion, which can both sting and spray its kurtoxin venom. [2] The first droplet of venom differs from the rest, and is referred to as "pre-venom". [4] A further potassium channel inhibitor, parabutoxin, has been isolated from the venom of P. transvaalicus. [5]