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The stepped-wedge design involves the collection of observations during a baseline period in which no clusters are exposed to the intervention. Following this, at regular intervals, or steps, a cluster (or group of clusters) is randomized to receive the intervention [5] [6] and all participants are once again measured. [7]
Edrecolomab (MAb17-1A, trade name Panorex) is a mouse-derived monoclonal antibody targeting the cell-surface glycoprotein EpCAM (17-1A), which is expressed on epithelial tissues and on various carcinomas. Preliminary studies had shown promise of a possible use in patients with stage III colorectal carcinoma (with metastasis to the lymph nodes).
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Dental panoramic radiograph showing Stafne defect in the right mandible, below the inferior alveolar nerve canal (arrowed, appears on lower left of image). This x-ray was taken for an unrelated assessment of wisdom teeth, and the Stafne defect was a chance finding.
A new review reports that nine people taking semaglutide and tirzepatide — the active ingredient in GLP-1 medications — experienced vision issues, including three potentially blinding eye ...