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Melatonin may be useful in the treatment of delayed sleep phase syndrome. [9] Melatonin is known to reduce jet lag, especially in eastward travel. However, if it is not taken at the correct time, it can instead delay adaptation. [30] Melatonin appears to have limited use against the sleep problems of people who work shift work. [31]
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[citation needed] Products containing melatonin are available as a dietary supplement in the United States [citation needed] and Canada. In 2009 agomelatine (Valdoxan, Melitor, Thymanax) was also [clarification needed] approved in Europe and is indicated for the treatment of major depressive disorder in adults.
Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.
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