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Lenacapavir was approved for medical treatment in the European Union in August 2022, [10] [12] in Canada in November 2022, [5] [6] and in the United States in December 2022. [9] [11] [13] [14] It is the first of a class of drugs called capsid inhibitors to be approved by the US Food and Drug Administration (FDA) for treating HIV/AIDS. [11] [15]
Food and Drug Administration (FDA) approval date: European Medicines Agency (EMA) approval date: Health Canada approval date: Company: Single-tablet regimen? NRTIs / NtRTIs: NNRTI: INSTI: PI: PK enhancer: Combivir: lamivudine zidovudine: September 26, 1997 ViiV Healthcare: No Kaletra (developed countries) Aluvia (developing countries) lopinavir ...
Gilead's Sunlenca, whose common name is lenacapavir, is given once every six months as an injection, but will be in addition to the current treatment regimen of patients. ... U.S. FDA approves ...
Lenacapavir, an antiretroviral drug typically used to treat HIV infections, can also effectively prevent them, a phase 3 clinical trial has shown. Lenacapavir injection lowers HIV risk by 96% Skip ...
The pharma giant has already secured approval for the injectable drug in treating highly drug-resistant HIV. Lenacapavir’s current list price for use as HIV treatment is $3,450 per month.
The binding pocket for Lenacapavir was first described in 2009, with the small molecule PF-3450074 (PF74) developed by Pfizer. [15] PF74 was not developed clinically due to its fast metabolic breakdown and poor bioavailability , but its binding pocket has been well characterized and frequently targeted.
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