Ad
related to: misoprostol parietal cell cancer
Search results
Results From The WOW.Com Content Network
Misoprostol is used for the prevention of NSAID-induced gastric ulcers.It acts upon gastric parietal cells, inhibiting the secretion of gastric acid by G-protein coupled receptor-mediated inhibition of adenylate cyclase, which leads to decreased intracellular cyclic AMP levels and decreased proton pump activity at the apical surface of the parietal cell.
The PPIs are given in an inactive form, which is neutrally charged and readily crosses cell membranes into intracellular compartments (like the parietal cell canaliculus) with acidic environments. In an acid environment, the inactive drug is protonated and rearranges into its active form.
These new agents can in a reversible and competitive fashion inhibit the final step in the gastric acid secretion with respect to K + binding to the parietal cell gastric H + /K + ATPase. That is, they block the action of the H + /K + ATPase by binding to or near the site of the K + channel. Since the binding is competitive and reversible these ...
The mifepristone-misoprostol combination is, by far, the most recommended drug regimen for medical abortions, but other drug combinations are available. Misoprostol alone, without mifepristone, may be used in some circumstances for medical abortion, and has even been demonstrated to be successful in the second trimester. [37]
Hyperplasia of parietal cells causes an abnormal release of HCl into the duodenum, which causes the ulcers of the duodenum. Excessive HCl production also causes hyperperistalsis, [ 14 ] a condition marked by excessive rapidity of the passage of food through the stomach and intestine and inhibits the activity of lipase , causing severe fatty ...
Omeprazole irreversibly blocks the enzyme system on parietal cells that is needed for the secretion of gastric acid. It is a specific H + /K + ATPase inhibitor. This is the enzyme needed for the final step in the secretion of gastric acid.
When the polyps are biopsied, the pathology typically shows shortened gastric pits, and both superficial and deep cystic lesions in the fundic glands, lined by all three types of cells of acid-producing mucosa: mucous, parietal and chief cells. As sometimes parietal cell hyperplasia may develop deep dilations of gland, [5] one should be really ...
stimulate dendritic cell maturation (antigen presenting cells of skin & mucosa) inhibit antibody B cell proliferation; ↑ inflammatory region blood flow (pyogenic & erythema) Inhibitory effects of dorsal root ganglion (speculated reduction in allodynia & hyperalgesia) ↓ gastric acid secretion; ↑ gastric mucus secretion; Prostate cancer ...