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Tirzepatide has a greater affinity to GIP receptors than to GLP-1 receptors, and this dual agonist behavior has been shown to produce greater reductions of hyperglycemia compared to a selective GLP-1 receptor agonist. [14] Signaling studies reported that tirzepatide mimics the actions of natural GIP at the GIP receptor. [35]
The gastric inhibitory polypeptide receptor (GIP-R), also known as the glucose-dependent insulinotropic polypeptide receptor, is a protein that in humans is encoded by the GIPR gene. [ 5 ] [ 6 ] GIP-R is a member of the class B family of G protein coupled receptors . [ 7 ]
A large study published in Nature Medicine reviewed the effects of GLP-1 drugs like Ozempic and Mounjaro on 175 different health outcomes. The findings show benefits for brain and heart health ...
[1] [2] Short-chain fatty acids (primarily acetic, propionic, and butyric acids), which microganisms form in the intestines, bind to the FFAR2 and FFAR3 receptors on K cells and L cells to stimulate their respective production and secretion of GIP [3] and GLP-1. [4] Both GLP-1 and GIP are rapidly inactivated by the enzyme dipeptidyl peptidase-4 ...
The difference here is that tirzepatide is a glucose-dependent insulinotropic polypeptide (GIP) receptor agonist and a GLP-1 receptor agonist. That means Mounjaro targets two receptors in the body ...
GLP1 poly-agonist peptides [1] are a class of drugs that activate multiple peptide hormone receptors including the glucagon-like peptide-1 (GLP-1) receptor.These drugs are developed for the same indications as GLP-1 receptor agonists—especially obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
Narimon Honarpour, Amgen's head of global clinical development, said combining a GIP receptor blockade with GLP-1 stimulation had the strongest impact on weight reduction compared to other strategies.
In accordance with the expression of GLP-1 receptor on brainstem and hypothalamus, GLP-1 has been shown to promote satiety and thereby reduce food and water intake. Consequently, diabetic subjects treated with GLP-1 receptor agonists often experience weight loss as opposed to the weight gain commonly induced with other treatment agents. [2] [15]