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  2. HIV integration - Wikipedia

    en.wikipedia.org/wiki/HIV_integration

    Structural domains of the HIV-1 integrase. The integration of HIV DNA into the host DNA is a critical step in the HIV life cycle. Understanding the integration process will provide a framework for gaining insight into multiple potential sites of therapeutic intervention for HIV infection and AIDS.

  3. Integrase - Wikipedia

    en.wikipedia.org/wiki/Integrase

    Retroviral integrase (IN) is an enzyme produced by a retrovirus (such as HIV) that integrates (forms covalent links between) its genetic information into that of the host cell it infects. [1] Retroviral INs are not to be confused with phage integrases ( recombinases ) used in biotechnology , such as λ phage integrase, as discussed in site ...

  4. Discovery and development of integrase inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    Raltegravir is an INSTI integrase inhibitor which inhibits both HIV-1 and HIV-2 replication. It is more potent than other previously known integrase inhibitors as well as causing less side effects. Raltegravir, Elvitegravir, Dolutegravir, Bictegravir and Cabotegravir are the only HIV-1 integrase inhibitor being used to treat HIV infections S ...

  5. HIV - Wikipedia

    en.wikipedia.org/wiki/HIV

    Two types of HIV have been characterized: HIV-1 and HIV-2. HIV-1 is the virus that was initially discovered and termed both lymphadenopathy associated virus (LAV) and human T-lymphotropic virus 3 (HTLV-III). HIV-1 is more virulent and more infective than HIV-2, [20] and is the cause of the majority of HIV infections globally. The lower ...

  6. Integrase inhibitor - Wikipedia

    en.wikipedia.org/wiki/Integrase_inhibitor

    Integrase inhibitors were initially developed for the treatment of HIV infection, but have been applied to other retroviruses. The class of integrase inhibitors called integrase strand transfer inhibitors (INSTIs) are in established medical use. Other classes, such as allosteric integrase inhibitors (ALLINIs) or integrase binding inhibitors ...

  7. HIV capsid inhibition - Wikipedia

    en.wikipedia.org/wiki/HIV_capsid_inhibition

    This process involves both viral and cellular proteins which reverse transcribe the viral RNA to double-stranded DNA, and incorporate the viral DNA into the host cell genome. [3] The capsid surrounding the viral RNA, nucleocapsids, reverse transcriptase, and integrase plays a key role in the infection process. The capsid is composed of amino ...

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