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Metabolic syndrome is a clustering of at least three of the following five medical conditions: abdominal obesity, high blood pressure, high blood sugar, high serum triglycerides, and low serum high-density lipoprotein (HDL). Metabolic syndrome is associated with the risk of developing cardiovascular disease and type 2 diabetes. [1]
Different definitions of the cardiometabolic syndrome have been proposed by different public health organizations, but recently the International Diabetes Federation (IDF), the National Heart, Lung, and Blood Institute (NHLBI), the American Heart Association (AHA), and others proposed a definition for diagnosing the cardiometabolic syndrome that includes the presence of three out of the ...
According to the National Heart, Lung, and Blood Institute, (NHLBI) about 1 in 3 American adults has metabolic syndrome. While the exact causes of metabolic syndrome are unclear, recent research ...
No universally accepted criteria exist to define putative MHO, [2] but definitions generally require the patient to be obese and to lack metabolic abnormalities such as dyslipidemia, impaired glucose tolerance, [1] or metabolic syndrome.
Ruiz agrees, explaining that being sedentary increases the risk of developing heart disease, stroke, diabetes, obesity and metabolic syndrome. Prolonged periods of inactivity can lead to poor ...
In males, obesity and metabolic syndrome both increase estrogen and adipokine production. This reduces gonadotropin-releasing hormone, in turn reducing both luteinizing hormone and follicle stimulating hormone. The result is reduction of the testis' production of testosterone and a further increase in adipokine levels. This then feeds back to ...
Among antipsychotic drugs for treating schizophrenia clozapine is the most effective, but it also has the highest risk of causing the metabolic syndrome, of which obesity is the main feature. For people who gain weight because of clozapine, taking metformin may reportedly improve three of the five components of the metabolic syndrome: waist ...
Like women, males with Klinefelter syndrome also have two copies of the X chromosome, which may predispose them to increased risk of autoimmune disease through the same mechanism. [44] This risk is highest in autoimmune diseases which are female-predominant (e.g., Addison's disease, multiple sclerosis, Sjögren syndrome). [ 44 ]