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However, further research is needed in the form of randomised trials to demonstrate its role in the treatment of benzodiazepine withdrawal. [ 89 ] [ needs update ] Flumazenil stimulates the up-regulation and reverses the uncoupling of benzodiazepine receptors to the GABA A receptor , thereby reversing tolerance and reducing withdrawal symptoms ...
Long-term use of benzodiazepines can induce perceptual disturbances and depersonalization in some people, even in those taking a stable daily dosage, and it can also become a protracted withdrawal feature of the benzodiazepine withdrawal syndrome. [54] In addition, chronic use of benzodiazepines is a risk factor for blepharospasm. [55]
Antipsychotics are generally a first-line treatment for delirium; however, when delirium is caused by alcohol or sedative hypnotic withdrawal, benzodiazepines are a first-line treatment. [84] There is some evidence that low doses of benzodiazepines reduce adverse effects of electroconvulsive therapy. [85]
With long-term use and during withdrawal of benzodiazepines, treatment-emergent depression and [7] emotional blunting may emerge and sometimes also suicidal ideation. There is evidence that the higher the dose used the more likely it is benzodiazepine use will induce these feelings.
The FDA also approves it for the treatment of generalized anxiety disorder (GAD). ... to take a benzodiazepine along with the medication for the first few weeks, as benzodiazepines can help reduce ...
The protracted withdrawal syndrome from benzodiazepines, opioids, alcohol and other addictive substances can produce symptoms identical to generalized anxiety disorder as well as panic disorder. Due to the sometimes prolonged nature and severity of benzodiazepine, opioid and alcohol withdrawal, abrupt cessation is not advised. [13]
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