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In the UK, the Royal College of Physicians developed the National Early Warning Score (NEWS) in 2012 to replace local or regional scores. [16] [17] [18] The NEWS score is the largest national EWS effort to date and has been adopted by some international healthcare services. [1] A second version of the score was introduced in 2017.
Epstein–Barr virus–associated lymphoproliferative diseases (also abbreviated EBV-associated lymphoproliferative diseases or EBV+ LPD) are a group of disorders in which one or more types of lymphoid cells (a type of white blood cell), i.e. B cells, T cells, NK cells, and histiocytic-dendritic cells, are infected with the Epstein–Barr virus (EBV).
Chronic active EBV infection or in its expanded form, chronic active Epstein–Barr virus infection is a very rare and often fatal complication of Epstein–Barr virus (EBV) infection that most often occurs in children or adolescents of Asian or South American lineage, although cases in Hispanics, Europeans and Africans have been reported. [1]
This photomicrograph depicts leukemia cells that contain Epstein–Barr virus using a FA staining technique. Epstein–Barr virus, EBV, is a member of the Herpesvirus family, and is one of the most common human viruses. When infection with EBV occurs during adolescence or young adulthood, it causes infectious mononucleosis 35% to 50% of the time.
While EBV is present in the salivary glands of normal individuals, a high incidence of EBV reactivation in Sjögren's patients has been reported with increased levels of EBV DNA. This indicates viral reactivation and inability of lymphoid infiltrates to control EBV replication in Sjögren's syndrome, leading to the initiation or perpetuation of ...
The Gammaherpesvirinae subfamily is associated with episomal latency established in cells of the immune system, such as B-cells in the case of Epstein–Barr virus. [ 3 ] [ 4 ] Epstein–Barr virus lytic reactivation (which can be due to chemotherapy or radiation) can result in genome instability and cancer .
EBV reactivation can occur in the B lymphocytes of CLL/SLL and lead to a severer form of CLL/SLL and/or to Richter's transformation. [23] RT transformation has been reported to rarely underlie the development of DLBCL-RT but is associated with the development of type 1 HL-RT in 75% of 51 type 2 cases and 65% of 26 type 1 cases. [ 20 ]
Evidence-based medicine (EBM) is "the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients. ... [It] means integrating individual clinical expertise with the best available external clinical evidence from systematic research."