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Phencyclidine is a noncompetitive NMDA receptor antagonist that blocks the activity of the NMDA receptor to cause anaesthesia and analgesia without causing cardiorespiratory depression. [ 61 ] [ 17 ] NMDA is an excitatory receptor in the brain, when activated normally the receptor acts as an ion channel and there is an influx of positive ions ...
A list of drugs or therapeutic agents administered via inhalation. Inhalational anesthetic agents ... Inhalant – non-medical drugs administered via inhalation
Pulmonary drug delivery is mainly utilized for topical applications in the lungs, such as the use of inhaled beta-agonists, corticosteroids and anticholinergic agents for the treatment of asthma and COPD, the use of inhaled mucolytics and antibiotics for the treatment of cystic fibrosis (CT) and respiratory viral infections, [1] and the use of inhaled prostacyclin analogs for the treatment of ...
Phencyclidine (PCP) is believed to be the first arylcyclohexylamine with recognized anesthetic properties, but several arylcyclohexylamines were described before PCP in the scientific literature, beginning with PCA (1-phenylcyclohexan-1-amine) the synthesis of which was first published in 1907.
NMDA receptor antagonists induce a state called dissociative anesthesia, marked by catalepsy, amnesia, and analgesia. [1] Ketamine is a favored anesthetic for emergency patients with unknown medical history and in the treatment of burn victims because it depresses breathing and circulation less than other anesthetics.
3-HO-PCP acts as a high-affinity uncompetitive antagonist of the NMDA receptor via the dizocilpine (MK-801) site (K i = 30 nM).[1] [3] It has much higher affinity than PCP for this site (K i = 250 nM, for comparison; 8-fold difference). [3]
Procyclidine, 1-cyclohexyl-1-phenyl-3-pyrrolidinopropan-1-ol, is synthesized in exactly the same manner as was seen for trihexyphenidyl, except this time the linear synthesis begins with the preparation of 3-(1-pyrrolidino)propiophenone. Procyclidine synthesis 2 [4] In an interesting variation, the ketone is first reacted with phenylmagnesium ...
A chemical weapon agent (CWA), or chemical warfare agent, is a chemical substance whose toxic properties are meant to kill, injure or incapacitate human beings.About 70 different chemicals have been used or stockpiled as chemical weapon agents during the 20th century, although the Organisation for the Prohibition of Chemical Weapons (OPCW) has an online database listing 35,942 chemicals which ...